How do molecular and clinical factors guide personalized selection of HSRT dose fractionation regimens with bevacizumab in recurrent high-grade gliomas?

Multivariate analysis identifying HSRT dose fractionation, tumor grade, IDH mutation, and 1p/19q codeletion as significant predictors of progression-free survival (PFS) in recurrent high-grade glioma strongly supports a shift toward biomarker-driven stratification in future trials. These findings un...

Is there a size limitation to SRT for recurrent GBM? I traditionally have always done the 35/10 Fogh regimen for anything over 3 cm. However, now with this data, I'm feeling I need to be a bit more aggressive with fractionated radiosurgery. Anyone doing 30/5 for 5 cm+ recurrences with Avastin?