How do you approach a young patient with metastatic poorly differentiated thyroid cancer with rhabdoid/non-anaplastic features?

Unfortunately, this patient has a very poor prognosis. Due to the nature of her tumor being poorly differentiated, her disease is more likely than not to be refractory to radioiodine. If her disease in the thyroid and neck has not been addressed, external beam radiation therapy should be offered for...

Unfortunately, this is an aggressive tumor that will not respond to RAI. While details of the case are not known (extent of disease, prior treatment such as thyroidectomy etc...), I would treat this as anaplastic, with NGS testing ASAP and target-specific treatment if appropriate. If no specific act...

Locally advanced thyroid cancer, multimodality treatment

Poorly differentiated thyroid cancer occupies a middle ground between differentiated thyroid cancers and the very terrible anaplastic thyroid cancer.

If your patient was able to have a total thyroidectomy, I would not completely rule out I-131 therapy as it seems your patient requires an all-hands-o...