How do you approach adding colchicine to a patient who is on a stable statin regimen?

This is a good question and a tough situation, since the drug-drug interaction here can be as subtle as myalgias but as severe as rhabdomyolysis (rare but happens). If you can avoid long-term colchicine in this situation, it is always best. These situations (hypercholesterolemia and crystal arthropa...

Interactions with P450/3A4 system is a great risk in those patients. I will decrease both medications doses or, after talking to PCP, stop for a short time the statin dose if PCP agrees.