How do you approach adjuvant therapy for treatment of a high-grade astroblastoma?

Astroblastomas are rare and have historically not been assigned a grade by the WHO but there are plenty of cases where more malignant behavior has been observed. We now know that this is due to the fact that multiple types of tumors can have the characteristic astroblastoma pseudorosettes which have been cited as a defining feature. Most of these tumors end up being PXA or HGNET tumors with MN1 alterations but some may be misdiagnosed LGGs or supratentorial RelA fused ependymoma. A good molecular neuropath workup can help differentiate what the exact diagnosis and elucidate what the probable clinical behavior/prognosis will be, but you are still left with how to manage the case in the meantime. The best clinical data on this tumor is probab...