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How do you approach adjuvant treatment of non-uterine leiomyosarcoma?

When, if ever, do you utilize adjuvant RT or chemotherapy?
1 Answer
Mednet MemberInvited Expert
Medical Oncology · Emory University
Answered on

I do not offer adjuvant chemotherapy to persons with leiomyosarcoma. One can make a case that the large negative randomized study EORTC 62931 published in 2012 supplants the 2008 meta-analysis of smaller studies that showed survival benefit from adjuvant chemo.

Woll et al., PMID 22954508

Neither is there data that adjuvant chemotherapy improves survival in uterine leiomyosarcoma.

One can find plenty of pro-adjuvant chemo and anti-adjuvant chemo articles in the scholarly literature. Baldini et al....

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