How do you approach cisplatin dosing for locally advanced head and neck SCC in HPV-positive and HPV-negative patients?
Specifically, is weekly 40 mg/m² considered equivalent to high-dose 100 mg/m² q3wk?
Community PollStarted
What is your preferred cisplatin dosing for locally advanced HNSCC concurrent with RT?
224 physicians have voted
Join Mednetto vote and see how they answered.
2 Answers
Mednet MemberInvited Expert
Medical Oncology · University of Michigan Medical School
Answered on
Weekly cisplatin 40 mg/m² is not yet considered equivalent to high-dose cisplatin 100 mg/m² every three weeks, and high-dose cisplatin remains the preferred regimen for both HPV-positive and HPV-negative locally advanced head and neck squamous cell carcinoma. However, weekly cisplatin is an acceptab...
Join for free or sign in to see the full answer
Mednet MemberInvited Expert
Radiation Oncology · University of Texas MD Anderson Cancer Center
Answered on
As Dr. @Dr. First Last points out, the NRG has an active study to address this. 100mg/m2 had been the standard, in part as an old ECOG trial published in abstract only tested a much weaker weekly regimen, i.e., 20 mg/m2, and was negative, while in particular the 2 seminal PORT trials testing cisplat...
Join for free or sign in to see the full answer