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How do you approach colon cancer chemotherapy in a patient who has had documented coronary vasospasm with FOLFOX?

Is re-challenge with 5-FU safe? Do you consider Capecitabine?
1 Answer
Mednet Member
Mednet Member
Medical Oncology · University of Texas MD Anderson Cancer Center
Answered on

Although there are case reports of successful rechallenging with infusional 5-FU in the setting of calcium channel blocker treatment, I don't endorse this approach given the potential cardiac consequences. Capecitabine is not an appropriate alternative since it's just infusional 5-FU in a different ...

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