How do you approach continuation versus cessation of systemic therapy for patients with stage IV triple negative breast cancer with a prolonged complete response to therapy and who are tolerating therapy well?

This is a difficult question to answer. Prior studies in metastatic breast cancer that tested chemotherapy holiday showed inferior survival as compared to maintaining or attenuating systemic therapy (examples: Coates et al., PMID 3683485; Stockler et al., Breast Cancer Research and Treatment 2003; J...