How do you approach dosing of anakinra in MAS?

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What is the maximum dose of anakinra you would use to manage MAS?

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1 Answer

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Pediatric Hematology/Oncology · UCSF Medical Center-Mission Bay

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We generally start with dosing per the rheumatology guidelines of 100 mg/day (1-2 mg/kg in children) subcutaneously. Based on case reports, if this is insufficient to control the hyperinflammation, can be increased (see Ajeganova et al., PMID 33281955).

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