I have a low threshold to recommend long term (indefinite) anticoagulation for unprovoked thrombosis, regardless of whether there is positive APLS testing. I do agree with Dr. @Broder, however, that shared decision-making is important when committing a patient to prolonged anticoagulation, and regul...

In the absence of strong evidence or guidelines, this would be a case-by-case decision. I would probably be inclined not to anticoagulate indefinitely, however, shared decision making with the patient is key.Several variables to consider would be other traditional risk factors, the presence of other...

If the patient already had an unprovoked DVT, and has had persistently low to moderate titers of APL antibodies, I think you need to consider some type of therapeutic intervention. At the very least, even though the evidence is not strong in the medical literature, I would consider using HCQ, stoppi...

Classifying the aPL profile as high- or low-risk, in conjunction with concomitant risk factors, can provide a general estimate of risk. Aspirin is recommended for primary prevention in individuals who have SLE and aPL, or in those without SLE but who have a high-risk profile.For patients who have AP...