How do you approach monitoring for lymphoproliferative disease in Sjogren's patients?

Topics: Hematologic Malignancies • Rheumatology • Hematology • Sjogren’s syndrome

Answer from: at Community Practice

I have an increased index of suspicion for lymphoma, myeloma, and amyloid in Sjogren's. Increased age, longer disease duration, and greater disease activity increase the lymphoproliferative risk.Persistent unilateral parotid or other salivary gland enlargements, lymphadenopathy, vasculitis (purpura,...

Comments

at Novant Health
Thanks. How often do you get SPEP/UPEP on your Sjo...

at University of California, Berkeley and San Francisco
Not often, but like to have a "baseline" so I know...

at Novant Health
Thanks.

at Marian Regional Medical Center
I just saw a new patient with SS and B cell lympho...

Answer from: at Community Practice

@Frank Scott:For your patient of SjD, B-cell lymphoma and severe sicca; in addition to your txing them with HCQ, I would also: Be diligent with treating the sicca sxs proactively to prevent dental loss and vision problems using the previous guidelines (Zero et al., PMID 26762707 and Foulks et al., ...

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