How do you approach monitoring for lymphoproliferative disease in Sjogren's patients?

2 Answers

Mednet Member

Rheumatology · University of California, Berkeley and San Francisco

I have an increased index of suspicion for lymphoma, myeloma, and amyloid in Sjogren's. Increased age, longer disease duration, and greater disease activity increase the lymphoproliferative risk.

Persistent unilateral parotid or other salivary gland enlargements, lymphadenopathy, vasculitis (purpura,...

Mednet Member

Rheumatology · Uniformed Services University of the Health Sciences (USUHS)

@Dr. First Last:

For your patient of SjD, B-cell lymphoma and severe sicca; in addition to your txing them with HCQ, I would also:

Be diligent with treating the sicca sxs proactively to prevent dental loss and vision problems using the previous guidelines (Zero et al., PMID 26762707 and Foulks et al....