How do you approach non-surgical patients with GIST who are intolerant to imatinib 400 mg daily and unlikely to tolerate other TKIs?
Do you reduce the dose to <400 mg daily or employ dosing schedules?
Answer from: Medical Oncologist at Academic Institution
Great question! I usually try splitting it first: 200 in the am and 200 in the pm. I also aggressively manage side effects. If still a problem, I may have to reduce the dose.