How do you approach non-surgical patients with GIST who are intolerant to imatinib 400 mg daily and unlikely to tolerate other TKIs?
Do you reduce the dose to <400 mg daily or employ dosing schedules?
1 Answer
Mednet MemberInvited Expert
Medical Oncology · University of Miami Sylvester Comprehensive Cancer Center
Answered on
Great question! I usually try splitting it first: 200 in the am and 200 in the pm. I also aggressively manage side effects. If still a problem, I may have to reduce the dose.
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