How do you approach patients with unresectable pancreatic cancer on gemcitabine/nab-paclitaxel-based chemotherapy q28 days with severe neutropenia?

Topics: Gastrointestinal Cancers • Medical Oncology

Would you consider dose reduction versus adding C-GSF?

Answer from: Medical Oncologist at Academic Institution

I always give gem-nab-pac every other week from the outset. So I rarely run into this issue, and when I do, it is easy, on a q2 week schedule, to add pegfilgrastim.

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Medical Oncologist at Thomas Jefferson University Hospital
I've also tended to favor this approach in practic...

Answer from: Medical Oncologist at Community Practice

Cytopenias and eventually, neuropathy are the major limiting toxicities of the three on and one-off dosing schedules of Gemcitabine and Nab-Paclitaxel. Previously, data has shown that every other week dosing is less toxic, more tolerable, and has the same efficacy (Ahn et al., PMID 28203300).We are,...

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Medical Oncologist
Since this is a patient with unresectable rather t...

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