How do you approach staging and treatment for a p16+ nasopharyngeal SCC?
How do you stage? Like nasopharynx or p16+ oropharynx?
Do you treat it like npx ca with chemo xrt + adj chemo or like opx p16+ with definitive chemo xrt . Would you use weekly chemo?
For radiation volume, do you include the oropharynx when treating p16+ NPX SCC?
2 Answers
Mednet MemberInvited Expert
Radiation Oncology · Memorial Sloan Kettering Cancer Center
Answered on
First question is whether it is strictly p16 positive and confirmed EBER ISH negative. If so, I treat it like p16 positive oropharyngeal cancer with chemoradiation. I don't give adjuvant chemo. All the adjuvant chemo or induction chemo data is for EBER ISH positive nasopharyngeal carcinoma.
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Mednet MemberInvited Expert
Radiation Oncology · University of Florida
Answered on
Treat like nasopharynx with chemo RT. I’m not a fan of post RT adjuvant chemo.
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