How do you approach the initial dosing of carfilzomib for patients with relapsed multiple myeloma?

Topics: Hematologic Malignancies • Medical Oncology • Myeloma • NCI-CCC Tumor Board Question • Hematology • Emory University • NCI-CCC Myeloma Tumor Board Question

Is the therapeutic purpose of the proteasome inhibitor to maximize total dosage per week or number of infusions per week?

Answer from: Medical Oncologist at Academic Institution

A great question and one without a uniform answer! I place a lot of focus on patient quality of life, and one of the recurring themes from patients is the number of visits to the medical center. A twice-weekly regimen of carfilzomib (or bortezomib for that matter), over the course of a year, re...

Comments

Medical Oncologist at Clinical Instructor
Dr. @Ben Derman, how do you dose carfilzomib in re...

Medical Oncologist at University of Chicago
If it is a deep response (i.e. CR), and at least 8...

Answer from: Medical Oncologist at Academic Institution

Could not agree more with Dr. @Ben Derman. "Home time" is tremendously important to our patients, and the efficacy bar to default to twice-weekly carfilzomib should be quite high to justify its use. As two quick additions to his expert comments: We will someday have an answer about twice-weekly 27m...

Related Questions