How do you approach the initial dosing of carfilzomib for patients with relapsed multiple myeloma?

A great question and one without a uniform answer!

I place a lot of focus on patient quality of life, and one of the recurring themes from patients is the number of visits to the medical center. A twice-weekly regimen of carfilzomib (or bortezomib for that matter), over the course of a year, results...

Could not agree more with Dr. @Dr. First Last. "Home time" is tremendously important to our patients, and the efficacy bar to default to twice-weekly carfilzomib should be quite high to justify its use. As two quick additions to his expert comments:

1. We will someday have an answer about twice-weekly ...