How do you approach the re-challenge with trastuzumab in metastatic HER2+ patients who develop cardiomyopathy on trastuzumab/pertuzumab with subsequent improvement with discontinuation?
Do you repeat the loading dose of trastuzumab?
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Do you re-load trastuzumab in patients who you are re-challenging in HER2+ metastastic breast CA who previously developed cardiac dysfunction?
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1 Answer
Mednet MemberInvited Expert
Medical Oncology · Icahn School of Medicine at Mount Sinai
Answered on
First, I send all my patients in this situation to the cardiologist. Second, I will re-start the treatment with close cardiology follow-up. Whether to re-load or not is an open question. I personally do not re-load, but I don’t think is wrong to re-load.
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