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What adjuvant therapy would you offer a postmenopausal woman with a new pT2N0 HR+/HER2+ breast cancer primary who is concurrently being treated with anastrozole/ribociclib for well controlled oligometastatic HR+/HER2- disease?  

The new primary was incidentally picked up on re-staging scans for the metastatic ER+ cancer. Would you modify the CDK4/6i and AI? What HER2 therapy would you offer?



Answer from: Medical Oncologist at Academic Institution
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