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Topics:
Hepatology • Viral Hepatitis
How do you approach the surveillance and serologic evaluation of a patient in whom you suspect has a hepatitis B pre-core mutant?
What findings would suggest to you that a patient has a pre-core mutant?
Answer from: at Academic Institution
HBeAg- HBeAb+/- with HBV DNA > 2 log likely precore mutant. Surveillance similar to wild-type with ALT and HBV DNA q6mos to assess for reactivation (abnormal ALT, DNA > 2000IU) that you would consider treating. If considering treatment, qHBsAg might be useful to identify patients who might be ...
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