How do you approach the use of anticholinergic medications that are prescribed for patients for non-cardiac issues, given evidence that increased anticholinergic burden may elevate the risk of out-of-hospital cardiac arrest?

Diminishing vagal tone should always be approached with caution because of the potential for adverse cardiovascular outcomes. These include sudden death as well as the potential for ischemic events caused by increasing oxygen demand. However, we need to be careful not to extrapolate these concerns t...