How do you approach titration or transitioning to Cobenfy in patients currently on an antipsychotic?  

Antipsychotics with significant anticholinergic activity, such as olanzapine and clozapine, can add to the effects of trospium contained in xanomeline-trospium combination. Product labeling reads "Concomitant use of COBENFY with other antimuscarinic drugs that produce anticholinergic adverse reactio...

I keep them on the antipsychotic that they are on, and depending on the response, I will slowly lower the original antipsychotic dose, but it depends on the patient. For example, I would start to lower the zyprexa and gauge for any reemergence of psychosis, but try and lower the zyprexa as much as p...