How do you approach treatment of an IDH wild-type low-grade astrocytoma in an elderly patient?
When would you offer hypofractionated radiotherapy?
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In IDH wild type LGG, which systemic therapy, if any, do you offer with radiotherapy?
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2 Answers
Mednet Member
Radiation Oncology · Turville Bay MRI & Radiation Oncology Center
Answered on · Updated on
Inherent in this good question are really two separate issues: 1) how to approach IDH-wt LGG and 2) how to treat glioma in the elderly (and/or frail).
The first issue is addressed by the recent cIMPACT-NOW update #3 which states that in the presence of an IDH-wt gr 2-3 glioma, the presence of one of ...
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Mednet MemberInvited Expert
Radiation Oncology · Florida International University
Answered on
Lower grade gliomas, especially IDH-mutant, tend to occur more commonly in younger patients. However, occasionally elderly patients are also diagnosed with WHO G2 astrocytoma. For example, in NRG Oncology RTOG 0424, a single arm phase 2 trial of RT plus temozolomide in high-risk low grade glioma, th...
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