How do you approach treatment of an IDH wild-type low-grade astrocytoma in an elderly patient?

Topics: Radiation Oncology • Neuro-Oncology

When would you offer hypofractionated radiotherapy?

Answer from: Radiation Oncologist at Community Practice

Inherent in this good question are really two separate issues: 1) how to approach IDH-wt LGG and 2) how to treat glioma in the elderly (and/or frail).The first issue is addressed by the recent cIMPACT-NOW update #3 which states that in the presence of an IDH-wt gr 2-3 glioma, the presence of one of ...

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Radiation Oncologist at UP Health System, Marquettte
It is worth mentioning that in the TCGA data set o...

Radiation Oncologist at Fox Chase Cancer Center
Review path. "LGG" in elderly (and WT) likely isn'...

Radiation Oncologist at Renown Health Institute for Cancer
How do you get TERT promoter, EGFR amp, +7/-10 inf...

Answer from: Radiation Oncologist at Academic Institution

Lower grade gliomas, especially IDH-mutant, tend to occur more commonly in younger patients. However, occasionally elderly patients are also diagnosed with WHO G2 astrocytoma. For example, in NRG Oncology RTOG 0424, a single arm phase 2 trial of RT plus temozolomide in high-risk low grade glio...

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