How do you approach treatment of an unresectable sacral chordoma?
What would be your preferred treatment technique and dose/fractionation?
3 Answers
Mednet MemberInvited Expert
Radiation Oncology · University of Florida
Answered on
Definitive RT, preferably with protons.
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Mednet Member
Radiation Oncology · Loma Linda University Health
Answered on
Agree. Definitive RT with protons.
79.2 Gy (RBE) in 44 fractions to GTV.
50.4 Gy (RBE) in 28 fractions to CTV.
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Mednet MemberInvited Expert
Radiation Oncology · The Ohio State University - James Cancer Hospital and Solove Research Institute
Answered on
As stated, definitive-intent RT. Evidence is strongest for protons, though SBRT is also a consideration. The available data are reviewed here: Konieczkowski et al., 32147017.
Outcomes for unresected chordomas are actually quite promising when treated at experienced centers—e.g., Kabolizadeh et al., P...
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