How do you approach use of tamoxifen for chemo-prevention in post-menopausal women with non-BRCA germline mutations?

I am not aware of any prospective studies specifically looking at non-BRCA mutations and tamoxifen’s role in chemoprevention in this population, although some retrospective studies in BRCA mutated patients have demonstrated a significant beneficial effect.

The NSABP breast cancer prevention trial dem...