How do you choose VOWST versus REBYOTA after an antibiotic course for recurrent C. difficile?

Just keep the patient on PO vanco 125 mg BID. That's plenty. Your GI tract would have to contain over 50 liters of fluid to dilute the vancomycin to a concentration below that of the C. difficile. Also, initial treatment should be longer than 10 days. I never understood the studies with a 10-day DOT...

Very non-scientific answer--whichever I can get! There are significant formulary and insurance issues with both, as well as whether you/your health system will help with the Rebyota colonic enema situation. If you can eliminate those barriers, I've not seen enough of either to be able to compare in ...