How do you counsel patients regarding alcohol intake when prescribing DMARDs other than methotrexate?

I always inquire about alcohol intake before starting any drug with a known issue of hepatotoxicoty, using the “Law of Two” I learned as an intern: alcohol abusers under-report their intake by a factor of two. Assuming there is no such red flag to avoid the drug, I tell my patients that alcohol is not absolutely forbidden, that a glass of champagne at a wedding or a glass or two of wine with dinner, if an uncommon event, e.g., no more than twice a week, is probably safe. If the patient drinks hard alcohol even on an irregular basis, I will stop the drug. If the patient reports more than this and certainly if alcohol intake is every night or heavier on weekends the “Law of Two” comes into play in my thinking and I will seek out another drug ...