How do you counsel premenopausal women with BRCA1 or BRCA2 mutations on the need for bilateral oopherectomy?

2 Answers

Mednet Member

Gynecologic Oncology · Cooper Medical School of Rowan University

I typically mirror the NCCN guidelines in this area. For those with BRCA 1 mutations, I recommend RRBSO between age 35-40 after completion of childbearing. Because those with BRCA2 mutations typically have onset of ovarian cancer later, it is reasonable to delay until age 40-45.

Counseling needs to ...

Mednet Member

Medical Oncology · University of Texas MD Anderson Cancer Center

It is reasonable to consider BSO late 30's for BRCA1 and early 40's for BRCA2 germline mutations.

How do you counsel premenopausal women with BRCA1 or BRCA2 mutations on the need for bilateral oopherectomy? | Mednet