How do you cross-taper when switching from an SSRI to an SNRI?

It depends on which SSRI and SNRI are involved, as well as the dose of the SSRI.

If switching from a low-dose SSRI, a cross-taper is not typically necessary given that both SSRIs and SNRIs increase serotonergic transmission and therefore a withdrawal effect will likely not be felt.

If switching from...

My first go-to is Lexapro, but let’s say I’m at 20 mg of Lexapro and it isn’t working then I switch to Effexor. Since there already is serotonin, I start Effexor at 150 mg because that's when the norepinephrine starts kicking in. It’s an SSRI at 75 mg. That way you get to the finish line sooner rath...