How do you deal with an interruption in definitive EBRT for prostate cancer?

The evidence that total treatment time matters in prostate cancer is pretty weak. In general, I would proceed as planned when the patient is able to resume without increasing the intended total dose. In this case, I would prefer not to stop at 60 Gy, as that dose probably would not be curative. Unless the patient has suffered a catastrophic medical event likely to significantly shorten his life expectancy, I would try to deliver the full 70 Gy dose.

In situations where the patient was not tolera...

Proceed as planned. Jim Parsons looked at our planned split course outcomes from the late 60s and early 70s, no difference in outcomes in contrast to the detrimental impact on head and neck.

We ran into this question in stark reality when a cyberattack shut down the entire Irish public radiation service last May. Our prostate patients were off treatment for almost three weeks. There isn’t a lot of data out there to support compensation - we elected to finish out treatment as planned without further amendment. This attack had catastrophic effects on cancer services in general and radiotherapy in particular. https://www.bbc.com/news/world-europe-58413448