How do you decide on dose modification, interruption, or discontinuation of temozolomide in the concurrent and sequential settings?

With regard to an optimal maintenance regimen, there is no data to suggest that an alternate regimen is more effective than the standard 150-200mg/m2 days 1-5 in a 28 day cycle. However, there are some patients that cannot tolerate this regimen due to excessive/ poorly controlled chemotherapy-relate...