How do you decide on the optimal neoadjuvant regimen for locally advanced GEJ cancer?

NCCN lists CRT as category 1 but also lists chemotherapy alone as an option. Is this decision based on discussion between surgeon and oncologist or is one approach clearly superior?

1 Answer

Mednet Member

Medical Oncology · University of Texas MD Anderson Cancer Center

Answered on

There is no randomized trial comparing the neoadjuvant chemo (MRC OEO2 or OEO5 trials) and neoadjuvant chemoradiation (CROSS trial) approaches in this setting. That being said, it's clear that chemoradiation produces more pathologic complete responses. Non-randomized data from MD Anderson (Swisher e...

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