How do you decide on the optimal neoadjuvant regimen for locally advanced GEJ cancer?

There is no randomized trial comparing the neoadjuvant chemo (MRC OEO2 or OEO5 trials) and neoadjuvant chemoradiation (CROSS trial) approaches in this setting. That being said, it's clear that chemoradiation produces more pathologic complete responses. Non-randomized data from MD Anderson (Swisher e...