How do you decide what induction chemotherapy regimen to use for a patient with locally advanced rectal cancer (cT4N1) receiving total neoadjuvant therapy?

The approach for a locally advanced rectal cancer (cT4N1) requires the consideration of many patient and cancer-specific factors. It is our practice that all new cases of rectal cancer undergo pelvic MRI including the use of rectal contrast to confirm staging with a dedicated assessment of nodal sta...