How do you diagnose MDS in a patient with equivocal morphological findings?
In the case of subtle single lineage dysplasia with normal cytogenetics, do you routinely perform NGS testing for CHIP-type clonal mutations?
Do you routinely perform any labs to rule out other causes of dysplasia?
Answer from: Medical Oncologist at Academic Institution
Cytopenic patients suspected of having MDS may often have equivocal findings in the bone marrow such as insufficient dysplasia and a blast proportion of less than 5%. This does not necessarily preclude a diagnosis if other features are present. For example, persistent, otherwise unexplained monocyto...
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