Myelodysplastic Syndromes   

Questions discussed in this category



Garcia-Manero et al., PMID 32285126Given the convenience of oral therapy, would you depend on the patient's ability to safely comply with the schedule...

Would a negative NGS eliminate the possibility of MDS? Is bone marrow biopsy indicated in a patient with pancytopenia with a negative NGS panel?

Do next generation sequencing results influence diagnostic and therapeutic decisions for patients with MDS?

If so, how do you incorporate GCSF into treatment of these patients?

For instance, if clonal hematopoiesis of indeterminate potential (CHIP) suspected 

In the case of subtle single lineage dysplasia with normal cytogenetics, do you routinely perform NGS testing for CHIP-type clonal mutations? Do you ...

Would this change with someone who has a history of thrombosis (e.g. DVT/PE, MI, CVA)? Would this change with someone who is more fit vs more frail?

Are there particular mutations (eg SF3B1) or syndromes (eg MDS/MPN overlaps such as MDS/MPN-RS-T) where you are more apt to using lenalidomide?

Can results from emerging AML data be extrapolated to high risk MDS populations? Is there data to guide the choice of continuing the HMA in combinati...

Given the rarity of this in MF, is it still predictive of response to lenalidomide therapy?


Papers discussed in this category


The Lancet. Oncology, 2009-03

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002-05-15

Cancer, 2011-06-15

American journal of hematology, 2009-09

Cancer, 2010-08-15

The New England journal of medicine, 2016-11-24

The Lancet. Haematology, 2018-01

Blood Adv,

Blood, 2015-11-19

Blood, 2017 Apr 19

Blood, 2021 Jul 13

Therapeutic advances in hematology, 2012-04

J Clin Oncol, 2021 Jan 13

American journal of hematology, 2019-04

Leukemia, 2023 May 05

Blood, 2018 Dec 13

N Engl J Med,

Am J Hematol, 2019 Aug 07

Blood, 2017-09-28

Haematologica, 2009-01

Blood, 2020 Jul 09

Leukemia, 2022 Dec 03

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-01-01

Nat Genet, 2020 Nov

Lancet (London, England), 2023 Jun 10