How do you differentiate a lupus flare versus drug-induced lupus in patients with SLE on a drug associated with DILE?

In my experience, the most common problem is drug-induced subacute cutaneous lupus erythematosus (DI-SCLE). Many drugs can cause the new onset of SCLE or the worsening of pre-existing SCLE. The list of SCLE-causing medications is extensive, growing, and includes common medications such as proton pum...

This is a great question and a problem that all of us face. It is important to remember that drug-induced lupus is in general a milder event. Most importantly, patients with drug-induced lupus would not have a central nervous system, cardiac, or renal presentations. If these are present, (new protei...