How do you differentiate between JAK2 positive ET and PV when peripheral blood shows erythrocytosis and thrombocytosis?

Topics: Medical Oncology • Myeloproliferative Neoplasms • Hematology • Pathology • Benign Hematology

Concordant low EPO level and bone marrow with megakaryocyte hyperplasia

Answer from: at Academic Institution

The answer to this question is very simple. Before the discovery of erythropoietin and accurate assays for it, and before the discovery of JAK2 driver mutations, the diagnosis of polycythemia vera was clinically-based. The Polycythemia Vera Study Group (PVSG) did an extensive epidemiologic study and...

Comments

Medical Oncologist at Southwest Medcl Consult SC
We are all so fortunate to have Prof @Jerry Spivak...

at Johns Hopkins University
Many thanks, Dr. @Rajalaxmi McKenna for your ...

Answer from: Medical Oncologist at Academic Institution

I imagine a pathologist would have a more precise answer here, however, when I see both thrombocytosis and erythrocytosis (especially with leukocytosis), I think the patient likely has PV as this disease is characterized by panmyelosis. The bone marrow morphology can further clarify the diagnosis- E...

Comments

Medical Oncologist at Taussig Cancer Institute
I agree with Dr. @Gabriela Hobbs! In general, if t...

Medical Oncologist at Kaiser Permanente-Santa Teresa-San Jose
If bone marrow biopsy is performed, it may disting...

Medical Oncologist at Wenatchee Valley Med Center
Is epo level ever low in ET?

at Johns Hopkins University
Yes.

Medical Oncologist at Thedacare Regional Medical Center-Appleton,Inc.
In PV with thrombocytosis (800k) and normal HCT (3...

at Johns Hopkins University
First, I assume that you are describing a woman PV...

at Lourdes Medical Center Burlington
I agree with Dr. @Spivak totally.

at MedStar Georgetown University Hospital
What if a bone marrow biopsy is done and it shows ...

at Johns Hopkins University
To begin, a bone marrow biopsy must be decalcified...

Related Questions