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How do you incorporate post-inflammatory pigmentary metrics (like the PCDA-Derm scale) into your therapeutic selection between IL-13 monotherapy, IL-4/13 dual blockade, and JAK inhibitors specifically when treating moderate-to-severe atopic dermatitis in patients with Fitzpatrick IV-VI skin?

Alexis et al. 2025 - American Journal of Clinical Dermatology: https://pubmed.ncbi.nlm.nih.gov/40665146/