How do you incorporate radiation therapy in patients undergoing CAR T-cell therapy for DLBCL?
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2 Answers
Mednet Member
Radiation Oncology · UMass Memorial Medical Group
It depends on the circumstances of the patient, but there are three emerging indications for RT in the setting of CAR T-cell therapy:
- Tumor debulking prior to CAR T-cell infusion
- Bridging therapy between apheresis and CAR T-cell infusion
- Salvage of refractory, progressive or relapsed disease follow...
Mednet Member
Radiation Oncology · Mayo Clinic College of Medicine and Science (Jacksonville)
Radiation can be incorporated with CAR-T in the bridging, consolidative and/or salvage setting.
Bridging radiotherapy benefits patients who present with:
- Rapidly progressive disease that needs to be controlled during the CAR-T manufacturing period (3-6 weeks). Lymphoma at this stage is chemoresistant...