Does significant eosinophilia (8-44%) in a patient with suspected granulomatosis with polyangiitis (GPA) based on sinusitis, pulmonary nodules and positive PR3 change your management approach?

This is an important question because at times the distinction between GPA and EGPA can be difficult to make. In general, I would rely on clinical symptoms as a key distinguisher. For example, sinusitis in GPA differs from that of EGPA, with the former often causing crusting, erosions/necrosis on EN...

High peripheral eosinophilia from any cause increases the risk of infiltrative disease, thrombosis (the eosinophils release major basic protein, which damages the endothelium and is a known hypercoagulable factor), and fibrosis. The risk of damage is high over an absolute eosinophil count of 1,500 a...