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How do you manage a possible autoimmune sialadenitis arising from checkpoint inhibitor therapy?

Pt with primarily oral sicca symptoms, but negative SS-A, SS-B. Mildly positive RF. Lack of improvement with first line xerostomia treatments.
1 Answer
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Mednet MemberInvited Expert
Rheumatology · Ohio State University
Answered on

This is a great question and a common clinical scenario in patients receiving immune checkpoint inhibitors. In my experience, severe sicca symptoms from immunotherapy are often not classic primary Sjögren's syndrome, despite some overlapping features. Rather, this appears to be an acute T-cell-media...

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