How do you manage grade 3 enterocolitis from 5FU mitomycin and pelvic radiotherapy?

With infection ruled out and CT showing diffuse enterocolitis extending far beyond the bowel-sparing IMRT radiotherapy field, presumably, it is due to the 5FU/mitomycin. In the few cases I have had, it generally heals 2-3 weeks after counts nadir. Besides supportive care (Imodium, Lomotil, Gas-X, tincture of opium, fluids) and "tincture of time", any other options?

Leave it to a rad onc to blame the chemo!! Joking aside, both modalities totally disrupt the Microbiome jointly. FU and MMC don’t produce segmental colitis. But given pan-colitis in this case, it seems likely mainly due to chemo.

Agree with supportive measures as above, bacterial probiotics, and tincture of time.