How do you manage grade 3 enterocolitis from 5FU mitomycin and pelvic radiotherapy?
C diff infection ruled out and CT abdomen pelvis shows diffuse enterocolitis extending far beyond the bowel-sparing IMRT radiotherapy field.
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How do you manage grade 3 enterocolitis from 5FU mitomycin and pelvic radiotherapy?
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2 Answers
Mednet Member
Radiation Oncology · The Oregon Clinic-Radiation Oncology West
Answered on
With infection ruled out and CT showing diffuse enterocolitis extending far beyond the bowel-sparing IMRT radiotherapy field, presumably, it is due to the 5FU/mitomycin. In the few cases I have had, it generally heals 2-3 weeks after counts nadir. Besides supportive care (Imodium, Lomotil, Gas-X, ti...
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Mednet MemberInvited Expert
Medical Oncology · Rutgers Cancer Institute of New Jersey
Answered on · Updated on
Leave it to a rad onc to blame the chemo!! Joking aside, both modalities totally disrupt the Microbiome jointly. FU and MMC don’t produce segmental colitis. But given pan-colitis in this case, it seems likely mainly due to chemo.
Agree with supportive measures as above, bacterial probiotics, and ti...
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