How do you manage grade 3 enterocolitis from 5FU mitomycin and pelvic radiotherapy?
C diff infection ruled out and CT abdomen pelvis shows diffuse enterocolitis extending far beyond the bowel-sparing IMRT radiotherapy field.
Answer from: Radiation Oncologist at Community Practice
With infection ruled out and CT showing diffuse enterocolitis extending far beyond the bowel-sparing IMRT radiotherapy field, presumably, it is due to the 5FU/mitomycin. In the few cases I have had, it generally heals 2-3 weeks after counts nadir. Besides supportive care (Imodium, Lomotil, Gas-X, ti...
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Answer from: Medical Oncologist at Academic Institution
Leave it to a rad onc to blame the chemo!! Joking aside, both modalities totally disrupt the Microbiome jointly. FU and MMC don’t produce segmental colitis. But given pan-colitis in this case, it seems likely mainly due to chemo.
Agree with supportive measures as above, bacterial probio...
Comments
Radiation Oncologist at The Oregon Clinic-Radiation Oncology West
100% agree radiotherapy will contribute in the pel...
100% agree radiotherapy will contribute in the pel...
Radiation Oncologist at Vanderbilt-Ingram Cancer Center
You may want to evaluate these patients for DPD de...
You may want to evaluate these patients for DPD de...