How do you manage hyperalgesia in patients with sickle cell disease?

In addition to the obvious, such as PCA narcotics, Lyrica/Neurontin, and Toradol, I have success with IV Tylenol, Zyprexa, po L-Arginine (Morris et al., PMID 23645695) as well as Dexmedetomidine (Precedex), steroids (NEJM: Griffin et al., PMID 8107739) and acupuncture [Johnson et al., Alternative and Complementary Therapies 2015].

Also mindfulness and attention to anxiety/ depression and social determinants of health, including racism and undereducated/unengaged internal medicine run hospitalist teams (instead of multidisciplinary sickle cell dedicated teams - as we see in pediatric hematology):

The Knowledge Gap No one Talks About: The Care and Understanding of Sickle Cell Disease - Paul M. Kent, MD.