How do you manage oxaliplatin-induced acute peripheral nerve hyperexcitability?

This can be very frustrating for both the patient and the treating physician, as there is little that we can do to prevent this from happening. I have found that assurance is the most important thing that we can do for patients. For example, some patients can develop pharyngolaryngeal dysesthesias (typically cold induced) and pseudolaryngospasm (not cold induced) in which they lose the sensation at the back of the throat/airway. It can give patients the sensation that they are having breathing t...

Anecdotally, in our practice, we had success with prolonging the oxaliplatin infusion time to 3 or 4 hours. Completely agree about irinotecan induced dysarthria mentioned by Dr. @Dr. First Last.