How do you manage patients with primary refractory Hodgkin lymphoma?
If a patient has an increase in PET avidity between the PET/CT done after 2 cycles of ABVD and after completion of chemo, how would you proceed? Would you consolidate RT to the PET avid disease sites? Would it be better to refer for salvage chemo +/- AutoBMT? Would a biopsy of the PET avid sites be indicated?
Answer from: Radiation Oncologist at Academic Institution
Without advising directly on this particular case, which is difficult to do without more information, a few principles in lymphoma management may be helpful:
1. Whenever there is discordance in the clinical picture, or whenever initial management would be drastically changed, it is always prudent t...
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