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How do you manage persistent hypokalemia and hypomagnesemia in an adult with Gitelman syndrome despite oral supplementation?

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What is your usual next step for persistent hypokalemia and hypomagnesemia in an adult with Gitelman syndrome despite oral supplementation?

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1 Answer
Mednet MemberInvited Expert
Nephrology · University of California, Los Angeles
Answered on

In patients with persistent hypokalemia due to Gitelman syndrome despite oral supplementation, I would add a potassium-sparing diuretic such as amiloride, eplerenone, or spironolactone. NSAIDS (e.g., indomethacin) may have a K-raising effect, but NSAIDS can potentially reduce kidney function. ACE in...

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