How do you modify Daratumumab-RVD relative to the protocols used in trials when used as a first-line agent to transplant-eligible patients with myeloma?
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1 Answers
Mednet Member
Medical Oncology · University of Nebraska Medical Center
My modifications based off the GRIFFIN trial (Voorhees et al., PMID 32325490) are as follows:
If patients have high burden disease and no underlying neuropathy, I will start with twice-weekly bortezomib (days 1, 4, 8, 11) but will change the dexamethasone to 20 mg days 1, 4, 8, 11, and 15 using the ...