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How do you optimize a beta thalassemia patient on luspatercept who is interested in becoming pregnant?

When do you stop luspatercept? How do you approach iron chelation therapy if the patient is currently on therapy?
1 Answer
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Pediatric Hematology/Oncology · Weill Cornell Medical College
Answered on

Unfortunately, luspatercept is not approved to be used during pregnancy - there is no data available on the safety of the drug during pregnancy. So would say that if the patient is planning a pregnancy, would stop luspatercept at least 3 months prior.

It is strongly recommended to optimize iron bala...

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