I recently had this approved for a gentleman with severe tophaceous gout who does not want to be on allopurinol due to mobilization flares and had anaphylaxis to pegloticase. He has CKD and multiple cardiac comorbidities which limit colchicine as prophylactic agent and difficulty with controlling bl...

I used canakinumab with allopurinol for a patient similarly with tophaceous gout and advanced CKD and frequent flares who was on a standing dose of PDN but had a concomitant infected diabetic foot ulcer. Canakinumab totally controlled his disease. It was amazing. However, he did have a temporally re...