How do you proceed after a patient has a partial response following 6 cycles of cisplatin + paclitaxel + bevacizumab +/- pembrolizumab for metastatic SCC of the cervix?

For a patient with minimal toxicity and evidence of a partial response receiving pembrolizumab, it is reasonable to continue treatment with chemotherapy + bevacizumab + pembrolizumab for a few more cycles. For patients not receiving pembrolizumab, I would continue treatment until unacceptable toxici...

Assuming PET scan is negative, proceed to laparoscopy --> excise any small colonies for genomics.

If positive, begin washings; only begin intra-peritoneal salvage therapy.

If PET scan is revealing, excise all residual lesions ---> new genomic evaluation of same.

Or Phase I--II protocols

Note: I have...